Due to current public health concerns, the Ohio Department of Education (ODE), like many state education agencies, is addressing the challenge of how to provide all prekindergarten through grade 12 students this fall with appropriate, standards-aligned, and evidence-based literacy instruction within the context of remote learning environments. Remote learning can be fully remote or some combination of a traditional in-person classroom setting and remote learning (e.g., a hybrid/blended format). The purpose of this white paper is to provide ODE and regional technical assistance staff with a multidisciplinary perspective on the challenge of providing all prekindergarten through grade 12 students with appropriate, standards-aligned, and evidence-based literacy instruction within the context of blended/hybrid learning environments. It is an initial attempt to integrate multidisciplinary information that may be relevant for addressing this challenge. This white paper also specifies implications for practice across different contexts (state and regional leadership systems, districts and schools, and educators and families) and disciplines (designing and delivering remote literacy instruction, new literacies in online research and reading comprehension, and home-school partnerships for literacy learning, likely impacting remote literacy instruction and learning).