The course of science is considered to boring and difficult course to be understood by students of science education program. The aims of this research are examine the effect of RMS learning model in mastering the students concepts; 2) examine the effect of difference academic ability in mastering students concept; 3) examine the effect of interaction between RMS learning model and different academic abilities on mastering students concepts. The method of this research is using quasi experimental design method with pretest and postest of non equivalent group design with factorial 2x2. The instrument of this study was essay test with high level of reliability 0.712. The Essay Test was developed based on Bloom's taxonomy i.e. remember, understand, apply, analyze, evaluate, and create. The data analysis used ANCOVA. The result showed that the average score for posttest in RMS learning model with high and low academic level are higher than posttest in conventional class with high and low academic level. The result of mastery of students concepts are higher, 16.233 compared to conventional learning models.