Low-income students in college face many challenges, including meeting college tuition and related costs as well as competing demands on their time from work, their studies, or family obligations. They may not be prepared for college academically. They may also lack the skills and experiences on which other students rely to help them navigate through college, or the social and family support that can help them overcome difficulties in college. MDRC has developed a deep body of evidence on interventions designed to help low-income college students succeed. This Issue Focus looks back over nearly 20 years of rigorous evidence on what works in postsecondary education to draw lessons that can help colleges and policymakers as they work to improve college completion rates for low-income students.