The United States has posted more than 100 consecutive months of net job gains since the economic recovery began in 2010, making this the longest expansion in seven decades. Yet, for many, wage growth has lagged, leaving many families economically insecure. Meanwhile, job and economic growth continue to accrue in select corners of the nation, leading to disparate economic and social outcomes across the country. This uneven progress reflects, in part, a nation grappling with an accelerating pace of change. Powerful new technologies have enhanced people's and firms' ability to achieve unprecedented productivity and have made the global economy more interconnected than ever. At the same time, these forces are making some skills and knowledge obsolete. As demand for specific knowledge and skills rises, the people and places that can meet these demands thrive, while others lose ground. The main objectives of this report are to: (1) Review the main underlying causes of structural change in the national labor market--from automation to digitalization to global competition--and the nature of the policy responses to date in addressing these challenges; (2) Propose a tailored approach to helping policymakers and companies bring economic growth to their regions by applying data-driven network analytics to reveal industry and city growth patterns within the U.S.; and (3) Demonstrate how the network analytics approach can inform local economic development strategies that foster growth and good jobs through four city-specific case studies: Nashville, TN; St. Louis, MO; South Bend, IN; and Boise, ID. [This report is a collaboration between the Center for Universal Education and the Metropolitan Policy Program at Brookings. Support from the MasterCard Center for Inclusive Growth.]