The purpose of this explanatory sequential mixed methods study was fourfold: examine the pre-service science teachers' pedagogical orientations about science teaching; examine the pre-service science teachers' beliefs about science teaching; establish the extent to which the pre-service science teachers' pedagogical orientations correlate with their beliefs; and establish factors that shape the pedagogical orientations and beliefs of pre-service science teachers. A sample comprised 140 secondary school pre-service science teachers at three universities in Zambia. There were 102 males and 38 females. In the first phase, data were collected using the Pedagogy of Science Teaching Test (POSTT) that was adapted to suit the Zambian curriculum, and the Teacher Beliefs Interview (TBI) protocol. Whereas, in the second phase, a semi-structured interview was used to collect data. Twelve pre-service science teachers were interviewed to solicit in-depth information on the findings from the POSTT and TBI protocol. Results show that pre-service science teachers' preferred pedagogical orientation was Guided Inquiry whereas their beliefs were mainly Transitional. There was no significant difference in pedagogical orientations and beliefs among pre-service science teachers whose subject majors were biology, chemistry, and physics. In addition, only pedagogical orientations used by pre-service science teachers whose science majors were biology and chemistry correlated. The study also shows that pre-service science teachers' beliefs and pedagogical orientations were not correlated. Furthermore, the study also revealed that factors which shaped pre-service science teachers' pedagogical orientations and beliefs were; curriculum, time constraints, resource availability, class size, school context, and educational background. These results have implications on science teacher education, teaching and learning of science, and science education research. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]