The purpose of this Brief is to define the variables a state or district leadership team may wish to consider as they determine if they are "ready" to invest in the scaling-up of an innovation in education. As defined here, "scaling up" means that at least 60% of the students who could benefit from an innovation have access to that innovation in schools across a State. Creating benefits to students on a comprehensive scale requires considerable change by teachers, building staff, district staff, and state leaders. "Readiness" is defined as a developmental point at which a person, organization, or system has the capacity and willingness to engage in a particular activity. Creating readiness for change is a critical component of both initiating and scaling up the use of evidence-based practices and other innovations in education. [For a related brief (2009), see ED507442.]