The purpose of this evaluation was to determine the impact of the Houston Independent School District (HISD) Literacy Empowered (LE) initiative on the reading, literacy, and performance in core courses among high school students. Literacy Empowered is a districtwide initiative that provides support for high school students through the expansion of "personalized instruction through the proficient use of PowerUP tools and authentic literacy practices across all core foundation classes in preparation for postsecondary education and/or careers." Students who constituted the study sample were linked to their teachers who completed the LE professional development (PD) by using unique identifiers. The evaluation was guided by four questions and surveyed teachers who completed the professional development (PD) associated with the LE initiative. Students' test data were analyzed, and treatment effect with regression adjustment was used to determine the impact of the initiative on students' performance. Multiple regression was used to predict the performance of LE students in the four core subjects assessed using the State of Texas Assessments of Academic Readiness (STAAR) End-of-Course (EOC) exams and regressed on key demographic and educational variables.