Career and Technical Education (CTE) programs focus on learning and building skills directly related to work and labor market demands, often for a particular sector or occupation. Previously referred to by names such as manual arts or vocational education, CTE takes place at the secondary (high school), postsecondary (college), and adult education levels. Programs are provided in educational institutions and real-world settings, with the latter including apprenticeships, on-the-job training, and a variety of intensive program models often geared toward opportunity youth (defined as young people between ages 16 and 24 who are neither enrolled in school nor working, constituting approximately one in nine 16- to 24-year-olds in the United States today). This brief highlights what research can tell us about these programs and their effects.