This chapter is structured for teaching young learners with physical (orthopedic) disabilities in special education. Orthopedic impairments encompass a range of disabling conditions. Orthopedic impairments are typically grouped into three main categories: (1) congenital anomalies (CA) such as absence of a member or clubfoot, (2) impairments caused by disease such as bone tuberculosis (TB) or poliomyelitis, or (3) impairments for other causes to include amputations, fractures, cerebral palsy (CP), burns, or fractures. In the chapter, the authors present definitions of various orthopedic impairments and discuss their respective etiologies followed by discussions of specific disabling conditions. Students with orthopedic impairments present both challenges and opportunities to special education teachers as is evident in the following case of Amira, a girl with asthma and CP. [For the complete volume, "Special Education for Young Learners with Disabilities. Advances in Special Education. Volume 34," see ED596193.]