This chapter features Indiana University's Instructional Systems Technology (IST) department. It highlights current theory and research that form the basis of improving learning and performance in diverse contexts. The contributions of professors Boling, Bonk, Brush, Cho, Frick, Glazewski, Haynes, and Reigeluth underscore IST's past, present, and future as its professors and students engage in the enterprise of teaching and research. Specifically, insight is provided on Boling's design research, Bonk's extreme learning, Brush, Ottenbreit-Leftwich and Glazewiski on problembased learning research, Cho's citation network analysis, Frick's theory of totally integrated education, Haynes on social cognitive theory, and Reigeluth's theory of instruction. [For the complete volume, "Educational Media and Technology Yearbook, Volume 37," see ED595734.]