Ensuring all youth, including youth with disabilities, graduate high school prepared to live independent, productive lives is the ultimate goal of high schools in the 21st century. Being prepared for post-school life means being college and career ready. Being college and career ready has been defined as "being prepared for postsecondary education without the need for remediation, which generally means that students have the academic background to do college level work". Students with disabilities are currently under performing when compared to students without disabilities and according to established benchmarks (National Center for Education Statistics, 2013). Therefore, in order to be college and career ready, they must be provided with the supports needed to improve their academic performance. The implementation of RtI in secondary schools is one promising practice to support youth with disabilities in developing appropriate skills to successfully complete high school and transition into post-school life. A variety of research has been conducted on RtI at the secondary level including descriptive, qualitative, and experimental/quasi-experimental studies. Descriptive research has examined the perceived importance and availability of RtI intervention practices (Sansosti, Noltemeyer, & Goss, 2010). The descriptive and qualitative research suggests several themes for successful implementation including: (a) implementing quality core instruction; (b) using progress monitoring measures related to core competencies; (c) having secondary and tertiary levels supplement, not replace, core instruction; (d) dedicating resources to implementation, including quality professional development; (e) changing the culture to facilitate RtI implementation including educators, parents, and community members; and (f) the use of evidence- and research-based practices throughout. This report provides many resources for RtI. Run by the American Institutes for Research, the Center on Response to Intervention provides support to states, districts, and schools with implementing RtI efforts. Additionally, the National Center on Intensive Intervention (http://www.intensiveintervention.org), funded through the U.S. Department of Education's Office of Special Education Programs, is a valuable resource for information on RtI.