Pearson sought to explore whether the use of Mastering Chemistry, an online tutorial system designed to help students with chemistry concepts, problem-solving skills and quantitative reasoning, is related to students' course scores and exam scores. This Research Report presents findings from two research studies: one correlational study conducted at a highly selective, four-year research university for students enrolled in a general chemistry course; and one quasi-experimental study conducted at Ohio State University, a primarily residential, land-grant public university known for academic research in science, for students enrolled in General Chemistry I and II. The aim in using mainly correlational study designs was to seek out possible relationships between the use of Mastering Chemistry and students' course and exam scores to identify areas of focus for potential future research using more rigorous causal study designs. The findings appear alongside details of the research studies, including descriptions of the samples studied, methods of analysis, results, limitations and generalizability, and notes on possible future research. The report also summarizes the context surrounding the findings, including the research that informed the design and development of the product, the history of the product in the market, how educators use the product, and its intended outcomes.