There is little extant theory framing the role of isolation in predicting various outcomes relating to the quality of work life of school principals. Building on previous work, this paper examines the relationships between isolation, self-efficacy, job satisfaction, burnout, and intention to leave the job using structural equation modeling on a sample of first-year principals from a Southeastern US state. Results affirm the import of isolation as an antecedent of each outcome, in particular principals' sense of efficacy.