Given the changing landscape in higher education, education practitioners are faced with increasing workloads, which in turn is causing an increase in stress-related factors that impede health and wellness, and thus productivity. In response, practitioners in modern higher education settings must adopt a commitment to self-care that focuses on the body, mind, and emotions, along with a healthy work-life balance, in order to not succumb to the negative impacts of stress in the workplace. In this article, we define various types of stress and related impacts; identify common stressors in the workplace; suggest strategies to enhance self-care and work-life balance; and summarize implications for practitioners in higher education. [For the complete proceedings, see ED590245.]