Although online education has become mainstream, not all online classes are created equal especially for people with disabilities, according to the authors. The differences between online and face-to-face classes are more than just a delivery method. Yet, many instructors and students are mired in the traditional approach to learning. Instructors often try to take face-to-face lecture materials and simply make them available online. Students may feel they need a synchronous component to be able to fully interact with the professor and classmates. As more and more research is collected on distance learning, the authors are beginning to see that online learning and new educational strategies are leading to high quality educational opportunities. Online classes are no longer just a last resort for those who cannot attend traditional classes; they are an equivalent option and perhaps even a better choice for some. The purpose of this publication is to assist agencies, institutions, and organizations in creating accessible online professional development opportunities, that adhere to Universal Design principles. Three appendices are included.