This research aims to determine the relationship between conversation and reading approach with social media and to find out their implication in inquiry-based learning. The author also aims to find out how social media as new literacies can help students to challenge and improve their responsibility in learning, also develop their skills and knowledge through giving comments, sharing information, and finding information resources. This case study is using quantitative method. The object of this study was the students in semester 6 in one of the university located in Tangerang. Data collection was done by conducting observations, questionnaires, and interviews. The results showed that using technology in supporting inquiry-based learning had positive impact on student's engagement with the class, and increased the student's capability of learning significantly. Furthermore, the results showed that there is a strong relationship between conversation and reading approach in inquiry-social media based learning, and that this learning model considered as effective for teaching and learning.