Clinical Question: For a preschool student with a severe phonological disorder, will incorporating a non-developmental target sequence be a more efficient approach than a developmental target sequence for improving speech sound production? Method: EBP Intervention Comparison Review. Sources: ASHA publications, PsycINFO database, PubMed database. Search Terms: phonological disorder, speech sound disorder, target selection, and non-developmental sequence. Number of Included Studies: 6 Primary Results: (1) When examining speech production changes of targeted sounds, results were equivocal with respect to the approach (i.e., developmental, non-developmental) to therapy target selection. (2) When examining generalization outcomes on untreated sounds, results favored the non-developmental approach to therapy target selection. Conclusions: (1) These studies indicate that incorporating a non-developmental approach may be more efficient in supporting widespread phonological learning; however, the effectiveness of this approach varies according to children's stimulability for target sounds. (2) SLPs should consider children's inventory of stimulable and non-stimulable sounds when deciding whether a non-developmental approach to therapy target selection is appropriate.