The importance of e-learning in our educational system as well as the nation's development cannot be over-emphasized. The use of e-learning in impartation and acquisition of knowledge by lecturers and students is becoming a vital tool in meeting the demands of education in the 21st century. The paper is aimed at exploring the prospects and challenges of e-learning towards promoting best practices in university education in Nigeria. It was discovered that effective communication between lecturers and students is enhanced through e-learning which has the potential to make learning to be realized faster and more efficiently than existing learning methods. However, literature revealed that the major challenges to e-learning remain that the various technologies used do not make provision for people who are visually impaired; unavailability of the equipment such as computers, digital technology, and internet for proper utilization due to cost; irregular supply of electricity, lack of both technical and social skills required for the implementation of e-learning. Recommendations made include the development of voice based e-learning applications for the visually impaired faculties and learners; recruitment of indigenous IT professionals for the development of low cost software packages; provision of incentives for private and non-governmental organisations that contribute to e-learning in Nigerian universities; Webinars, drills and workshops that engage participants in the active use of and development of e-learning technologies should be instituted at intervals. [For the complete proceedings, see ED579335.]