This dissertation explores and connects the concepts of self-creation and self-care as a means to better address the evolving needs of students seeking to actualize themselves in and beyond higher education. These needs include helping students manage change, and other issues such as stress, anxiety, substance abuse, and physical health challenges, as well as academic, career, and financial concerns. The methodology employed was a transdisciplinary, integrative approach. A critical review and analysis of theoretical and empirical literature examines self-creation and self-care from holistic, developmental, and transdisciplinary perspectives. This work culminates in the creation of a model defining their relationship and capacity for addressing holistic student wellness, well-being, development, and learning in higher education. The Self-Creation Self-Care (SCR/SCA) model is a practical contribution that is conceptually defined by the recognition of self-actualization, epistemological development, an evolutionary world view, agency, and embracing change as primary in the management of energy towards positive outcomes for student learning, development, wellness, and well-being. This model integrates content, context, and holistic approaches based on research that engages complexity, creativity, conflict and change, care, and consciousness. The SCR/SCA model creates the foundation for curriculum development in the context of higher education and beyond, with a value for the tools of scholarship, inquiry, practice, and support. This paradigm entails a fundamental shift in how the higher education experience is structured and imagined, offering an innovative means to broaden and deepen the college student's experience, satisfaction, and perceived return on investment. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]