Technical assistance (TA) has long been a standard, overarching strategy for assisting, states, agencies, family members, and practitioners with building capacity for service and system change initiatives. But, what is meant by the term "technical assistance"? What is known about the technical assistance strategies that are likely to achieve particular outcomes? How can technical assistance strategies promote both practice and systems change? The purpose of this Technical Assistance Center on Social Emotional Intervention for Young Children (TACSEI) Roadmap document is to assist a range of stakeholders (e.g., early childhood service providers, parents, technical assistance providers) in understanding the types of TA that are most beneficial for achieving particular practice and systems outcomes. The paper explores and highlights TA strategies to initiate, implement, and sustain effective practice and systems change. With this information, stakeholders at multiple levels (e.g., practice, organization, collaborative groups, state, Federal) will be better equipped to select, promote, and provide TA that is aligned with improving practice, organizations, and systems to serve young children with or at risk of disabilities with challenging needs.