Organization Development (OD) has been used in a variety of ways to improve organizations both large and small. Interestingly, the institutions that teach and conduct research on organizations have been slow to adopt or utilize OD approaches and practices in their own institutions. This dissertation will use a thematic meta-synthesis approach to examine the case studies that have been conducted in which OD initiatives have been used in Higher Education Institutions (HEIs) between 2000 and 2015. It will look to synthesize the main themes of these case studies in an effort to create a new grounded theory of OD practice for HEIs. The study looked at 34 case studies (12 articles and 22 dissertations) that took place at a mixture of public and private universities and colleges in the United States from 2000 to 2015. Using a qualitative thematic meta-synthesis approach allowed the research to uncover the prevailing themes and discuss in a macro sense how OD has been applied to HEIs. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]