This "Evidence for Education" is about helping students stay on track in math, building concept upon concept in a steady progression of skills. This is as much a national priority as it is a practical necessity for the students themselves, because daily life involves math--from the check-out counter at the school store to the express line in the grocery, from our most routine jobs to the high-paying, high-profile ones in engineering, technology, and science (Lee, Grigg, & Dion, 2007; U.S. Government Accountability Office, 2005). So--two questions naturally arise. What do students need to know how to do, mathematically? And what instructional approaches are effective in teaching those skills? This "Evidence for Education" addresses these questions, and one more: What do we do when disability affects a student's ability to learn math skills? This issue is divided into four sections, as follows: (1) The work of four expert panels, which have recommended what students need to learn in math and what we need to teach; (2) How disability can affect math learning; (3) Four instructional approaches emerging from the research as effective math interventions for students with disabilities; and (4) Suggestions for moving research into practice. A glossary is included.