The Kentucky System of Interventions (KSI) framework emphasizes optimizing instruction through targeted accelerated learning, development of teacher expertise and responsiveness to the needs of all learners. This approach to Response to Intervention (RtI) provides the structures needed for closing achievement gaps, ensuring readiness to learn and guiding students smoothly from preschool through post-secondary transitions that lead to learning success. The KSI model helps address readiness to learn as it serves children in a P-12 model. Students identified early, in preschool, can receive intervention services that will enable them to be more prepared for entry into kindergarten. The KSI model also helps address student transitions with a focus on individual academic performance and behavioral needs. Students who have identified needs (the universal and/or diagnostic screening measures, in addition to other data related to the students' progress) are provided interventions that are relevant and targeted to fulfill those needs. Collaboration and communication from one school to the next (especially in terms of transitioning from elementary to middle and middle to high school) will be especially important in supporting students during these pivotal transitional points. The Kentucky Department of Education (KDE) has expanded the framework for RtI assisting schools and districts in incorporating state and federal programs and providing a seamless system of intervention for improving achievement for all students. This guidance document provides resources to help schools and districts analyze their current systems (human, physical and financial resources and materials) and refine their decision-making processes to move forward to full implementation of a comprehensive instructional system (P-Grade 12). The following are appended: (1) Student Intervention System Readiness Tool; (2) School Implementation and Intervention Teams; (3) Intervention Legislation; (4) EPAS Interventions and Documentation; (5) Types of Acceleration; and (6) Elements in Each Tier.