In this essay, the authors accomplish three tasks: (1) identify common limitations of programs designed to increase the success rates of Latina/o college students, (2) describe the common characteristics of programs that exhibit effective practice, and (3) provide a framework to guide colleges and universities in designing effective program components that address the common factors impeding Latina/o student success in college. [This Scholarly Paper was commissioned for the 6th Annual Conference of the American Association of Hispanics in Higher Education, 2011.]