The purpose of this study was to explore the effect the integration of a multicultural curriculum has on the perceived level of cultural competence of physician assistant students. A convergent parallel mixed-methods approach was utilized to collect the necessary data. The physician assistant students participated in focus-group sessions and a cultural competence assessment. A paired samples t-test and repeated measures ANOVA were conducted and results indicated that students who participated in the multicultural curriculum reported a significant increase in perceived level of cultural competence, cultural awareness, cultural knowledge, and cultural skills as a result of the curriculum. Through coding, five themes emerged from the focus-group sessions and students reported advancement in their understanding of cultural desire, cultural awareness, cultural knowledge, cultural skills, and cultural encounters as a result of participating in the multicultural curriculum. The results suggested that the longitudinal integration of a multicultural curriculum increases students' perceived level of cultural competence, thus providing a multicultural curriculum is beneficial in the cultural competence of medical professional students. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]