The present study was conducted on 400 students (200 Boys and 200 Girls) selected from Senior Secondary School of A. M. U. Aligarh; India to establish the prognostic value of different measures of cognition, personality and demographic variables for success at Higher Secondary level in Science stream. The score obtained on different variables are factor analysed to get a smaller number of meaningful variables or factors to establish the predictive validity of these predictors. Factors responsible for success in Science stream were identified. The prognostic value of the predictors was compared with high achievers and low achievers in order to identify the factors which differentiate them.