The purpose of this sequential, explanatory mixed methods research study was to understand what factors influenced African American maternal intentions to get their daughters aged 9 years to 12 years vaccinated in Alabama. In the first, quantitative phase of the study, the research questions focused on identifying the predictive power of eleven variables, representing selected factors associated with maternal intentions to vaccinate their daughters. The data were collected via a self-developed instrument that used a mixed mode survey design that was web-based (N = 14) and paper-based (N = 228). Participant demographics were analyzed using descriptive statistics. A binary, logistic regression analysis identified four variables best predicting maternal intentions towards HPV vaccinating their daughters against HPV: perceived barrier: information; perceived barrier: daughter too young for the vaccine; culture: future-time orientation; and subjective norms. In the second, qualitative phase were selected from the quantitative phase to explore the results from the statistical tests in more depth. Nine participants were selected using a stratified proportional subgroup sampling design and a maximal variation principle. Data collection included use of semi-structured interviews from five participants with positive intentions and four participants with negative intentions. Seven themes related to maternal intentions to vaccinate their daughters against HPV emerged in the thematic analysis of each participant and across the participants: role of knowledge, interpersonal influences, personal experiences, cultural influences, benefits of HPV vaccination, barriers of HPV vaccination, and vaccination uptake recommendations. For each participant, the themes differed in the number and similarity subthemes comprising them. There were similarities and differences among the participants in the study, while there were more similarities among participants in each group (those with positive intentions and those with negative intentions). "Perceived barriers" and "future-time orientation" were the most discussed themes. "Vaccination uptake recommendations" and "interpersonal influences" were other reasons mothers chose to or not to vaccinate their daughters. The results of the quantitative and qualitative phases were integrated while interpreting the outcomes of the entire study. Based on the findings from the quantitative and qualitative phases of the study, recommendations were made for a theoretical, culturally-tailored intervention to promote HPV vaccination uptake among African American girls aged 9 to 12 years. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]