When studies are conducted over a period of time, the sample size typically decreases. In a study of the effects of exercise therapy and education with recovering congestive heart failure (CHF) patients (Brubaker, Witta, & Angelopoulus, 2003), the sample size decreased from over 40 to 9 participants after an 18-month time span. Although the quality of life (QOL) scales and measures of physical ability showed improvement, these results were limited to 9 participants. Thus, there was some question concerning the generalizability of this study to other patients with congestive heart failure. The purpose of this study was two-fold: (1) to use the bootstrapping procedure to provide the confidence intervals and estimate generalization error of both physical and quality of life results for that study, and (2) to estimate the probability of sample results as extreme as the observed sample using permutation methods. Most of the findings from this study support the findings from the original study and provide further evidence of the importance of the exercise and education treatment used in the original study. Further, this is not the only study in which improvement in physical measures and QOL constructs have shown improvement. Although the majority of studies on patients with CHF are less than six-months in duration, evidence has been provided that exercise tolerance and QOL can increase significantly following a supervised exercise program (Holst, Kaye, Richardson, Krum, Prior, Aggarwal, Wolfe, & Bergin, 2001; Quittan, Sturm,Wiesinger, Pacher, & Fialka-Moser, 1999; Tokmakova, Dobreva, & Kostianev, 1999).