The Business-Higher Education Forum (BHEF) has achieved particular success in operationalizing the National Higher Education and Workforce Initiative (HEWI) in Maryland around cybersecurity. Leveraging its membership of corporate CEOs, university presidents, and government agency leaders, BHEF partnered with the University System of Maryland to build a system-wide response to the state's (and nation's) cybersecurity workforce challenges. BHEF's work in Maryland illustrates that it is indeed possible to effect swift, significant change and innovation in higher education with the goal of better aligning curricula and student outcomes with needed workforce skills. This pace of change hinges on the genuine commitment, expertise, and investment of resources by motivated stakeholders. This case study describes how the Maryland regional initiative, as part of HEWI, operationalizes and implements the BHEF strategies.