The learning ability of students in science is improved by socio-scientific decision-making, an important activity that improves a student's scientific literacy, conceptual understanding, scientific inquiry, attitudes, and social values. The socio-scientific issues must be discussed during science classroom activities in the current state of 21st century skills. This paper expands upon how to enhance socio-scientific decision making in the classroom, presenting a detailed thematic review of socio-scientific decision which is relevant to research studies' needs, methods, general knowledge claims, and implications. The methods of studies consist of interviewing, class observation, open-ended questions, free writing, audio-tape recorded discussion, and role play. The result is that it can be recommended, taking into account their findings in teaching processes.