The 2012 National Survey of Science and Mathematics Education was designed to provide up-to-date information and to identify trends in the areas of teacher background and experience, curriculum and instruction, and the availability and use of instructional resources. This compendium, one of a series, details the results of a survey of high school biology teachers in schools across the United States. The report contains tables of frequencies for each item on the questionnaire, copies of the instruments, and detail on data collection and analysis.