This report presents the deliberations of the Southeast Regional Advisory Committee (RAC), one of 10 RACs established by the U.S. Department of Education, identifying educational challenges across the six states in the region: Alabama, Florida, Georgia, Mississippi, North Carolina and South Carolina. Committee deliberations took place May 23, 2011, through June 20, 2011, during which time the RAC members considered input from professional practice groups, public comments, and their own experiences and expertise. The Southeast RAC members noted that each challenge identified affects multiple stakeholders and represented multiple needs. To outline coordinated strategies for technical assistance to meet these needs, the RAC organized the highest priority stakeholder needs into three cross-cutting challenge categories: Providing customized instruction for all students; integrating appropriate, research-based practices into classrooms; and placing and retaining qualified and quality teachers in the most challenged and rural classrooms. Southeast RAC members recommended specific technical assistance to meet the needs for each category, and strongly advocate a global and coordinated approach to meet the interrelated needs and sustain systemic change. The RAC further believes that all the action items together form a cohesive, strategic approach to meet the overall challenges, and that such a strategic approach should inform any future assistance programs or centers provided by the U.S. Department of Education to the Southeast region. The cross-cutting challenges, priority needs, and the recommendations for technical assistance for the Southeast region are presented. Appended are: (1) Glossary of Abbreviations; (2) Regional Profile; (3) Challenges and Needs Identified by Southeast RAC; and (4) Public Comments. (Contains 4 figures, 25 tables and 6 footnotes.)