Thirty thousand young people who entered ninth grade in the School District of Philadelphia's Classes of 2000-05 failed to graduate four years later. Resulting losses are huge--to lifetime earnings and employment for these young people, to government revenues, and to the regional economy. Fortunately, a renewed interest in the out-of-school youth population in Philadelphia and across the country in recent years is leading to a growing understanding of the challenges faced by these young people, and to an increasing body of effective practices aimed at reconnecting them to high-quality educational opportunities with pathways to postsecondary education and careers. This paper presents research-based practices that reconnect out-of-school youth to education and employment. (Contains 8 footnotes.)