This paper presents the annual report of the National Math and Science Initiative (NMSI) for 2009. 2009 has been a tremendous year for the NMSI. The team members are working as an agent of change in the U.S. public education system, dramatically improving math and science education for young people. Its AP Training and Incentive Program (APTIP) has already produced impressive results. In the first year, the program schools in its six states produced a 52 percent increase in the number of AP courses passed in math, science, and English (MSE). One of the keys to success in APTIP is providing high-quality professional development for the existing teacher corps. In 2009, NMSI provided AP training to 478 teachers across the country. The second program, UTeach, works to build the quality of the future teacher corps. UTeach is bringing a new generation of math and science majors into the field of teaching. The heart of this program is ensuring the new teachers have deep math and science knowledge; the pedagogy in the program focuses specifically on how to teach math and science effectively. In the first year of replicating UTeach, the members have implemented the program in 13 universities nationwide--from coast to coast. The "freshman" class drew 1,100 students, and that enrollment has nearly doubled its second year. A list of funders for this program is included. [For 2008 annual report, see ED537890.]