This paper presents the annual report of the National Math and Science Initiative (NMSI) for 2010. Four years ago, NMSI was just an idea. NMSI not only hit the ground running in 2007, it picked up the best ideas in the country and rolled them out in schools and universities from coast to coast. Within a year of its creation, NMSI had awarded grants to six states to bring college-level Advanced Placement courses to more students, raising the bar in math and science education in public high schools. A new foundation was established for more students--rich or poor, urban or rural--to succeed in college. Grants were also awarded to 13 universities to implement the highly successful UTeach program to recruit, inspire and train the next generation of math and science teachers. This paper reports the documented progress made by NMSI in four years. Thousands more of young people are being prepared to succeed in college, careers, and life. In turn, that strengthens America. It will take an even more concerted effort to raise the bar in math and science education for more children. The nation needs a sustained investment in education and basic research to keep from slipping further behind. Congress, corporations and foundations must commit the necessary resources to effect change on an even broader scale. [For 2009 annual report, see ED537893.]