This 2010 Annual Report for the Missouri Department of Higher Education takes a close look at the performance of Missouri's system of postsecondary education in Fiscal Year 2010. The annual report follows the format of the state's public agenda for higher education, "Imperatives for Change: Building a Higher Education System for the 21st Century," which was first issued in 2008. "Imperatives for Change" is organized around three goals. Each section of this report includes measures for accomplishing the goals, sets a target for each measure and provides data to show progress toward the targets. The report also analyzes Missouri's strengths and weaknesses, how it compares to other states and the national average, and what programs and initiatives are under way to enhance progress toward goal attainment. More than 600,000 students attended 13 public four-year university campuses, 21 public two-year campuses, 25 independent colleges and universities and 163 private for-private (proprietary) schools in Missouri in Fiscal Year 2010. Missouri taxpayers provided more than one billion dollars to support public colleges and universities so students can pursue affordable options for higher education, including completion of postsecondary certificate and degree programs. Appended are: (1) Enrollment Charts; (2) Student Aid Programs; (3) College Access Challenge Grant; (4) Proprietary Enrollment; and (5) All Academic Program Actions. (Contains 3 footnotes.) [For the 2009 annual report, see ED537449.]