A new trend in e-learning development is to have subject matter experts use rapid development tools to create training simulations. This type of training is called rapid e-learning simulation training. Though companies are using rapid development tools to create training quickly and cost effectively, there is little empirical research to indicate whether training created in this manner meets the needs of learners. The purpose of this study was to compare user responses to rapid e-learning simulation training to user responses receiving instructor-led training. The target population for this study was employees of a medium size private company in North America. Employees were divided into two groups and either received instructor-led training (comparison group) or received rapid e-learning simulation training (experimental group). The instrument used to measure user response was an adaptation of the technology acceptance model. Three variables were measured: training satisfaction, perceived ease of use, and perceived usefulness. Though no statistical significance was found between the two groups for training satisfaction and perceived usefulness, perceived ease of use was found to be statistically significant. Overall results fail to demonstrate the superiority of rapid e-learning simulation training over instructor-led training; however, this study indicates that rapid e-learning simulation training may be a viable substitute for classroom instruction based on user response. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]