The study examined the relational-behavior survey (RBS) as a predictor of HIV-related parental miscommunication (HPM) among a voluntary sample 75 African American parents at a private healthcare facility located in the southwest region of the United States. A multiple regression analysis indicated that there was significant marginal prediction of the RBS factors (subjective knowledge, knowledge deficiency, relational skills, HIV/STD stigmatization, community empowerment, health distrust) with HPM (R = 0.38, p = 0.09); R squared = 0.14. In an exploratory MRA backward elimination procedure of the RBS factors and contextual variables (parental age, gender, educational level, and the number of children in the household,) there was a significant prediction of HPM (R = 0.51, p less than 0.01); R squared = 0.26. The backward elimination procedure further indicated that parental educational level and relational skills were the strongest predictors of HPM (R = 0.44, p less than 0.01); R squared = 0.19. Based on the findings, the RBS may be useful in the development of family-life skills programs at primary healthcare facilities. (Contains 1 table, 1 figure, and 2 charts.)