The purpose of this study is to design different hands-on science activities and investigate which activities could better promote female students' learning motivation towards science. This study conducted three types of science activities which contains nine hands-on activities, an experience scale and a learning motivation scale for data collection. Five hundred female students and three science teachers were recruited in this study. Three hundred students from all participants needed to fill out an experience scale about hands-on science activities and the other 200 students were divided into three groups and joined in different hands-on activities. All female students of three groups need to fill out the learning motivation scale before and after exercising hands-on activities. The results showed that all types of hands-on activities in this study could promote female students' learning motivation towards science, but the hands-on activities about daily life issues could better promote female students' learning motivation toward science than the others. This study suggested that hands-on activities should be considered in science teaching strategies. Science teachers and teaching material designers also need to design some science topics and activities which are closely related to daily life to promote female students' learning motivation towards science. (Contains 5 tables and 1 figure.)