As young people transition through childhood to adolescence, they often face developmental challenges that can impede their quest to become flourishing, healthy adults. While both males and females experience difficulties, there are certain risk factors to which males are more susceptible. Compared with females, males tend to be more likely to drop out of school, engage in delinquency, use alcohol, smoke cigarettes, and act out. They are also less likely than females to go to college. While a number of evidence-based programs have been found to be effective at reducing risk factors for children and adolescents, many programs have differential impacts for females and males. Understanding what works for male children adolescent is critical to improving outcomes for youth. This "Fact Sheet" and its companion "Fact Sheet," focused on female children and adolescents, examine programs and strategies that work, as well as those that don't work. This literature review synthesizes findings from 115 random assignment intent-to-treat evaluations of interventions that targeted male children and adolescents, or coed interventions that provide impact data specifically for male children and adolescents. Interventions were excluded from the review if they did not include at least 100 males in the evaluation sample. Overall, 57 of the 115 programs had a positive impact on at least one outcome reviewed, 27 had mixed findings, and 31 did not have any positive impacts for the males studied. While several themes emerged, the author did not find any one program or practice that worked across all outcome areas. (Contains 42 footnotes.) [For related report, "What Works for Female Children and Adolescents: Lessons from Experimental Evaluations of Programs and Interventions. Fact Sheet. Publication #2012-23," see ED535398.]