This Manual should serve as a primary resource for site operators. It is organized so that all sites, no matter where they are in their development, will be able to find the information and resources they need to grow their initiative. In addition to offering suggestions on how to organize and conduct activities, this Manual provides research and standards-based design features that are attractive to funding sources. Anything in this Manual may be adapted for a site's use. The structure for this Manual is as follows: (1) Chapter 1 introduces HS/HT and describes why it exists; (2) Chapter 2 lays the foundation for the program components and for the documented need for intervention strategies for youth with disabilities; (3) Chapter 3 explains the process of becoming affiliated with the HS/HT network; (4) Chapter 4 provides direction on how to start a new state or local site; (5) Chapter 5 provides a wealth of information on finding financial resources to sustain your site; (6) Chapters 6 through 9 describe the design features for the HS/HT program. The chapter structure for each design feature includes an introduction to the design feature, a description of how to prepare for and implement the design feature component, suggested timelines for implementing the activities, and a listing of exhibits (including a citation of research findings to support the design feature); (7) Chapter 10 focuses on program evaluation, reporting, and outcomes; (8) Chapter 11 discusses how to market HS/HT to a variety of audiences; (9) Chapter 12 contains a glossary of HS/HT terms; (10) Chapter 13 provides research references and further resources to site operators. Each chapter includes references. [This document was developed by the National Collaborative on Workforce and Disability for Youth.]