The SEPA (Science Education Partnership Award) is a NIH (National Institutes of Health) program to provide science education to children K-12. In 2009, the NIH provided a supplement to develop a curriculum to inform students about factors that affect the mental health of native Americans. The goal of the current project was to develop a behavioral health curriculum sensitive to native American values and present these materials in a four-day workshop to educators of native youth. A multi-month effort was required to: (1) develop a needs assessment from local tribal representatives; (2) obtain relevant cultural research; and (3) enlist tribal representatives to deliver portions of the curriculum. The adapted curriculum addressed content sensitive to American Indian cultural issues. These issues and others were addressed within the context of a four-day professional development workshop held on the campus of the University of Nebraska Medical Center, Omaha, N.E.. The workshop focused on two primary content areas: (1) factors related to the development and expression of maladaptive behaviors and mental illness; and (2) factors related to the development of healthy and adaptive behaviors. (Contains 1 table.)