Children who have at least one parent born outside the United States or U.S. territories presently make up almost one-quarter of the children in the country. Moreover, these children represent the fastest-growing segment of the U.S. child population. As of 2006, the majority of children of immigrants were Latino, with 41 percent of all child immigrants having parents from Mexico, 11 percent from Central America and the Spanish-speaking Caribbean, and 6 percent from South America. This brief identifies reasons that it is important to focus on children of Latino immigrants, discusses what out-of-school time (OST) programs can do for these children, and provides advice on how to attract and retain children of immigrants in these programs.