This paper reports a survey that sought to establish levels of use of PC (personal computer) software by graduate students in Makerere University and to link the same to organizational characteristics, related to a given respondent's "unit", that is school, faculty or institute, namely its ability to absorb change, its ICT (Information and Communication Technology) culture, size and leader's ICT change management style. The correlational and cross-sectional survey involved 175 students who filled a questionnaire. Data analysis, involving summary statistics (e.g., means and standard deviations) and multiple regression, indicated low levels of use of PC software, and only unit ICT culture was a significantly positive correlate of the same. It was thus recommended that stakeholders, such as the Makerere University directorate of ICT support, encouraged respective units to build and continually enhance their ICT cultures as a possible means of enhancing the use of PC software by graduate students therein. (Contains 6 tables.)