This paper explores some of the psychological and other issues associated with HIV infection in children. Although the majority of studies are in the West, a growing core of information is emerging from other centres. This paper attempts to summarise the complexity of who the children are, examine emerging orphan and vulnerability issues, explore HIV/AIDS treatment interventions and how they affect the emerging scenario in terms of child and parent infection, and then focus on the widespread psychological effects of HIV/AIDS on the young child. (Contains 4 tables.)