This guide was produced by the Center on Instruction for technical assistance providers and others who work with state education leaders to improve reading achievement among elementary school students. It describes a suite of "Student Center Activities" (SCAs) designed to offer K-5 classroom teachers a wide range of activities that can engage students in differentiated reading activities during small-group work in the classroom. Although these activities were prepared for use in Florida schools, they may be used in any elementary school context. They are consistent with scientific research on reading instruction and can be integrated easily into any core reading program that is based on the five essential components of reading (phonological/phonemic awareness, phonics, fluency, vocabulary, and comprehension). Elementary school teachers in Florida and other states have adopted the "Student Center Activities" variously in general education classrooms, as interventions, and in special education classes; middle school teachers have used the materials in intervention and special education classes. "Student Center Activities" Crosswalks are appended. (Contains 1 table.)