This issue of R&D Alert presents a sample what of works to strengthen mathematics and science education. The lead article describes the core principles of WestEd's National Academy for Science and Mathematics Education Leadership. After 5 years running the academy, WestEd staff have refined effective approaches for developing teacher leaders focused on these subjects. Another article shares new ideas for improving the preparation of mathematicians and scientists in higher education, drawing on an evaluation of the national "Preparing Future Faculty" program.