The Business-Higher Education Forum's (BHEF's) Securing America's Leadership in STEM Initiative has broken new ground in addressing one of the nation's most critical challenges--increasing the number of students who are interested in and pursue careers in science, technology, engineering or mathematics, the so-called "STEM" fields. The Initiative, which identified as its goal the doubling of U.S. bachelor's degrees earned in STEM fields, produced the first simulation model of STEM education in the United States. The BHEF U.S. STEM Education Model (the Model), developed by Raytheon Company and donated to BHEF, has provided a number of powerful insights about the highest leverage points and potential strategies that can lead to increased numbers of students who are proficient in STEM fields, and who may pursue STEM careers. It has also pointed to the need for a comprehensive, national STEM education strategy that targets critical leakage points in the STEM education pipeline, and to the need for new, more sophisticated tools that can help guide policymakers and educators. Among the most significant insights from this multi-year effort are: (1) Increasing the number of STEM college graduates will require a carefully integrated (in fact, mutually reinforcing) P-12 and higher education strategy; (2) Improving persistence and student success in STEM undergraduate education can produce significant returns in the near term; (3) Increasing the number of STEM-capable teachers is vital to increasing the number of students who choose and succeed in STEM majors; and (4) In addition to increasing student proficiency in STEM subjects, the United States must increase students' interest in STEM majors and careers. Securing America's Leadership in STEM Initiative: Working Group 2010 is appended. (Contains 6 figures and 7 footnotes.)