Research suggests youth anxiety increases the chance of risky behaviors and academic difficulties, whereas spirituality moderates. To confirm these findings, this research investigated the nature of spirituality and trait anxiety on at-risk factors in high school youth. The Intrinsic Spirituality Scale, the State-Trait Anxiety Inventory, and the Risk Factors Assessment for School Youth were administered to 105 youth attending a public high school in US Mountain West Region. Analyses of variance ANOVA and covariance ANCOVA statistics revealed that there was a significant inverse relationship of spirituality and a significant positive relationship of trait anxiety to total risk. When spirituality and trait anxiety were examined together, spirituality had a marginal moderating effect on the significant relationship of trait anxiety to total risk. Race/Ethnicity was found to be a significant predictor of total risk from the variables studied. The results of this research confirmed the findings of previous research. Limitations of this study, implications of this study, suggestions for counselors and educators, and recommendations for future research are provided. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com.bibliotheek.ehb.be/en-US/products/dissertations/individuals.shtml.]