This research is attempting to examine the effectiveness in the application of ICT (information and communication technology) and standardize courseware in ETeMS (English for Teaching Mathematics and Science) or PPSMI (Pengajaran and Pembelajaran Sains and Matematic dalam Bahasa Inggeris) in English program in the Malaysian secondary school system. Five dimensions of secondary school (type of school, demographic, leadership quality, teaching and learning culture, and teachers' personal and working experience) were examined to determine the maximizing usage of TEC (technology-enhanced classroom) in the learning program. In general, there is a significant difference among factors stated above with maximizing usage of TEC in teaching and learning of science and mathematics in English program. The learning culture is also closely related. In addition, the school and teaching staff are another two essential factors found to be the strong fundamental of maximizing the usage of technology in TEC teaching and learning with towering quality. This study represents an addition to the extant literature on maximizing the usage of technology-enhanced teaching and learning towards the excellence of education in the secondary school system. The maximizing usage of TEC teaching and learning environment within the secondary school system is pivotal towards achieving high quality human capital and improving the efficiency and integrity of technology-enhanced learning of science and mathematics in English program. This study provides further groundwork to assist existing education managers to improve work quality and deliver the maximizing usage of TEC teaching and learning towards the excellence in secondary education. (Contains 5 tables and 1 figure.)